ʻO ka ʻike ʻana iā ʻoe he lymphoma hiki ke lilo i manawa koʻikoʻi loa, akā ʻo ka loaʻa ʻana o ka ʻike kūpono hiki ke kōkua i ka hōʻemi ʻana i kou kaumaha a kōkua iā ʻoe e hoʻolālā i mua. E hāʻawi kēia ʻaoʻao iā ʻoe i ka ʻike o ke ʻano o ka lymphoma, pehea ka ulu ʻana o nā cell, a me ke kumu e ulu ai ka lymphoma, nā hōʻailona o ka lymphoma a me kāna mālama ʻana a me nā loulou pono.
ʻO ka Lymphoma kahi ʻano maʻi maʻi e hoʻopilikia i kou mau koko i kapa ʻia he lymphocytes. ʻO nā Lymphocytes kekahi ʻano o ke koko keʻokeʻo keʻokeʻo e kākoʻo ana i ko mākou ʻōnaehana pale ma ke kaua ʻana i nā maʻi a me nā maʻi. Noho lākou i loko o kā mākou ʻōnaehana lymphatic me ka liʻiliʻi loa i loaʻa i loko o ko mākou koko. Ma muli o ko lākou noho nui ʻana i loko o kā mākou ʻōnaehana lymphatic, ʻaʻole ʻike pinepine ʻia ka lymphoma ma nā hoʻāʻo koko.
ʻO kā mākou ʻōnaehana lymphatic ke kuleana no ka hoʻomaʻemaʻe ʻana i ko mākou koko mai nā mea ʻawaʻawa a me nā mea ʻino a me kā mākou lymph nodes, spleen, thymus, tonsils, appendix a me kahi wai i kapa ʻia he lymph. ʻO kā mākou ʻōnaehana lymphatic kahi kahi e hana ai kā mākou lymphocytes B-cell i nā antibodies e hakakā ana i ka maʻi.
Ua kapa ʻia ʻo Lymphomas i ka maʻi kanesa o ke koko, ka maʻi kanesa o ka ʻōnaehana lymphatic a me ke kanesa o ka ʻōnaehana pale. Akā ma mua o 3 mau ʻano o ka maʻi kanesa, hāʻawi kēia mau huaʻōlelo i ka mea, kahi a me pehea. E kaomi i nā pahu huli ma lalo no ka ʻike hou aku.
Ka mea
Ka mea
ʻO nā pūnaewele B, e hana ana i nā antibodies e hakakā i ka maʻi.
ʻO nā pūnaewele T hiki ke hakakā pololei i ka maʻi a hoʻopaʻa i nā mea pale ʻē aʻe.
ʻO nā pūnaewele NK - kahi ʻano kūikawā o ka cell T.
ʻO kahi
ʻO kahi
Ka Pehea
Ka Pehea
Hoʻopilikia kēia i ka hiki o kāu ʻōnaehana pale ke mālama iā ʻoe i ke olakino a pale iā ʻoe mai nā maʻi a me nā maʻi.
Inā ʻaʻole i loaʻa iā ʻoe, makemake paha ʻoe e kipa i kā mākou ʻaoʻao ma ka hoʻomaopopo ʻana i kāu ʻōnaehana lymphatic a me nā ʻōnaehana pale ma ke kaomi ʻana i ka loulou ma lalo nei. ʻO ka hoʻomaopopo ʻana i kāu lymphatic a me nā ʻōnaehana pale e kōkua iā ʻoe e hoʻomaopopo maʻalahi i ka lymphoma.
Loaʻa iā mākou ʻelua ʻano nui o nā lymphocytes:
- B-cell lymphocytes a me
- T-cell lymphocytes.
ʻO ia ke ʻano hiki iā ʻoe ke loaʻa i ka lymphoma B-cell a i ʻole lymphoma T-cell. ʻO kekahi mau lymphoma kakaʻikahi he mau lymphomas Killer cell maoli (NK) - ʻo nā pūnaewele NK he ʻano o T-cell lymphocyte.
Hoʻohui hou ʻia ʻo Lymphoma i Hodgkin Lymphoma a me Non-Hodgkin Lymphoma.
He aha ka ʻokoʻa ma waena o Hodgkin a me Non-Hodgkin Lymphoma?
- Hodgkin Lymphoma - ʻO nā Lymphomas Hodgkin āpau he lymphomas o nā lymphocytes B-cell. ʻIke ʻia ʻo Hodgkin Lymphoma i ka wā e ulu ai nā pūnaʻi B maʻi maʻi ma kekahi ʻano a lilo Nā pūnaewele Reed-Sternberg - ʻokoʻa loa ka nānā ʻana mai nā pūnaʻi B maʻamau. ʻAʻole nā pūnaewele Reed-Sternberg i nā Lymphomas Non-Hodgkin. Loaʻa i nā pūnaewele Reed Sterberg kekahi pūmua kikoʻī i kapa ʻia ʻo CD15 a i ʻole CD30 ma luna o lākou. kaomi i 'aneʻi e aʻo hou e pili ana i ka lymphoma Hodgkin.
- Lymphoma Non-Hodgkin (NHL) - ʻO kēia nā lymphomas o nā pūnaʻi B ʻē aʻe a i ʻole nā lymphocytes T-cell, me nā pūnaewele NK. Manaʻo ʻia ʻo Chronic Lymphocytic Leukemia (CLL) he subtype o ka NHL no ka mea, ʻo ia ka maʻi like me Lymphocytic Lymphoma liʻiliʻi. Aia ma mua o 75 mau ʻano subtypes o NHL. No ka ʻike hou aku e pili ana i nā ʻano ʻano like ʻole, kaomi i ka loulou ma lalo nei.
No ka hoʻomaopopo ʻana i ka lymphoma, pono ʻoe e ʻike iki i ke ʻano o ka ulu ʻana o nā sela o kou kino.
Pehea ka ulu maʻamau?
ʻO ka maʻamau ka ulu ʻana a hoʻonui ʻia nā cell ma kahi ala paʻa a hoʻonohonoho pono ʻia. Hoʻolālā ʻia lākou e ulu a hana i kekahi ʻano, a hoʻonui a make paha i kekahi mau manawa.
ʻO nā kelepona iā lākou iho he microscopic - ʻo ia hoʻi he liʻiliʻi loa lākou ʻaʻole hiki iā mākou ke ʻike iā lākou. Akā, ke hui pū lākou a pau, hoʻokumu lākou i kēlā me kēia ʻāpana o ko mākou kino e like me ko mākou ʻili, nā kui, nā iwi, ka lauoho, nā puʻupuʻu lymph, ke koko a me nā ʻāpana kino.
Nui nā mākaʻikaʻi a me nā kaulike e hōʻoia i ka hoʻomohala ʻana o nā cell i ke ala kūpono. Aia kēia mau mea i nā "immune checkpoints". ʻO nā wahi hoʻopaʻa palekana he mau kiko i ka wā o ka ulu ʻana o ke kelepona kahi e "hōʻoia ai" kā mākou ʻōnaehana pale ʻana he cell maʻamau a olakino.
Inā nānā ʻia ke kelepona a ʻike ʻia he olakino, hoʻomau ka ulu ʻana. Inā he maʻi, a he poino paha ma kekahi ʻano, hoʻoponopono ʻia a luku ʻia paha (make), a hoʻoneʻe ʻia mai ko mākou kino ma o kā mākou lymphatic system.
- Ke hoʻonui ʻia nā pūnaewele, ua kapa ʻia ʻo ia ʻo "ka mahele pūlima".
- Ke make nā pūnaewele, kapa ʻia ʻo ia ʻo "apoptosis".
Hoʻoponopono ʻia kēia kaʻina o ka mahele cell a me ka apoptosis e nā genes i kā mākou DNA, a ke hana nei i loko o ko mākou kino i nā manawa a pau. Hana mākou i ʻekolu mau cell i kēlā me kēia lā e hoʻololi i nā mea kahiko i hoʻopau i kā lākou hana a i ʻole i pōʻino.
Genes a me DNA
Aia i loko o kēlā me kēia pūnaewele (koe naʻe ke koko ʻulaʻula) he nucleus me 23 mau chromosomes.
Hoʻokumu ʻia nā Chromosomes i kā mākou DNA, a ʻo kā mākou DNA i hana ʻia i nā ʻano genes like ʻole e hāʻawi i ka "mea ʻai" no ke ʻano e ulu ai, hoʻonui, hana a make.
Hiki mai ka ma'i 'a'ai, me ka lymphoma a me ka CLL ke hiki mai ka poino a i 'ole ke kuhi hewa i ko kakou mau genes.
E aʻo hou aʻe e pili ana i ka hopena o kā mākou mau genes a me DNA i ka wikiō ma lalo nei. Mai hopohopo nui e pili ana i nā inoa o nā protein a me nā kaʻina hana, ʻaʻole koʻikoʻi nā inoa e like me kā lākou hana.
He aha ka mea maʻi?
ʻO ka maʻi maʻi he a ka genema'i tic. Hana ʻia ia i ka wā i loaʻa ai ka pōʻino a i ʻole nā hewa i loko o kā mākou ka genes, ka hopena o ka ulu ʻole ʻana o nā cell.
I ka lymphoma a me CLL, hiki mai ka ulu ʻole ʻia a me ka ulu ʻole i kāu lymphocytes T-cell a i ʻole B-cell.
ʻO kēia mau hoʻololi i kā mākou DNA i kekahi manawa i kapa ʻia ʻo genetic mutations a i ʻole genetic variations. Hiki ke hana ia ma muli o ke ʻano o ka nohona e like me ka puhi paka, ka pōʻino o ka lā, ka hoʻohana nui ʻana i ka waiʻona (nā hoʻololi i loaʻa), a i ʻole ma muli o nā maʻi e holo ana i loko o ko mākou mau ʻohana (nā hoʻololi hoʻoilina). Akā, no kekahi mau ma'i ma'i, 'a'ole mākou i 'ike i ke kumu.
He aha ke kumu o Lymphoma & CLL
ʻO Lymphoma a me CLL kekahi o nā ʻano maʻi maʻi maʻi kahi a mākou i ʻike ʻole ai i ke kumu. Aia kekahi mau mea pilikia i ʻike ʻia, akā nui ka poʻe me nā kumu pilikia like ʻole e hoʻomau i ka hoʻomohala ʻana i ka lymphoma a i ʻole CLL aʻo nā mea ʻē aʻe, me ka ʻole o nā kumu pilikia i ʻike ʻia.
Hiki i kekahi mau mea pilikia ke komo:
- Inā ua loaʻa iā ʻoe ka maʻi Epstein Barr (EBV). Hoʻokumu ka EBV i ka mononucleosis (ʻike ʻia ʻo "mono" a i ʻole ka maʻi glandular).
- ʻO ka maʻi hoʻopalekana kanaka (HIV).
- ʻO kekahi mau maʻi o kāu ʻōnaehana pale, e like me ka autoimmune lymphoproliferative syndrome.
- ʻO kahi ʻōnaehana pale nawaliwali ma hope o ka hoʻololi ʻana o ke kino a i ʻole ka stem cell. A i ʻole, mai kekahi mau lāʻau lapaʻau āu e lawe ai.
- He makua, kaikunāne, a he kaikuahine me ka moʻolelo pilikino o ka lymphoma.
Pono ka noiʻi hou aʻe e ʻike i nā kumu o ka lymphoma a me CLL. Ke ʻike ʻia kahi kumu, a laila hiki iā mākou ke ʻimi i nā ala e pale aku ai. Akā a hiki i kēlā manawa, ʻo ka ʻike e pili ana i nā hōʻailona o ka lymphoma, a ʻo ka ʻike mua ʻana i ke kauka ʻo ia ka manawa maikaʻi loa e hakakā ai.
Ka nānā 'ana o Lymphoma a me CLL
Hoʻopilikia ka Lymphoma ma mua o 7300 Australians i kēlā me kēia makahiki, a ʻo ia ka 6 o ka maʻi kanesa maʻamau i nā kāne a me nā wahine makua ma Australia, akā hiki ke hoʻopilikia i nā poʻe o nā makahiki āpau me nā keiki a me nā pēpē.
ʻO ia ka maʻi maʻi maʻi maʻamau i nā poʻe ʻōpio 15-29 mau makahiki, a ʻo ia ka 3 o ka maʻi kanesa maʻamau i nā keiki 0-14 makahiki. Eia nō naʻe, piʻi aʻe ka pilikia o ka hoʻomohala ʻana i ka lymphoma i ko mākou wā ʻelemakule.
He aha kaʻu e ʻike ai e pili ana i kaʻu lymphoma?
Aia ma luna o 80 mau subtypes like ʻole o ka lymphoma. ʻOi aku ka maʻamau o kekahi mau ʻano subtypes, a he kakaikahi kekahi. ʻOi aku ma mua o 75 o kēia mau subtypes he subtype o Non-Hodgkin Lymphoma, aʻo 5 he subtypes o Hodgkin Lymphoma.
He mea nui e ʻike i ke ʻano subtype i loaʻa iā ʻoe, no ka mea, hiki i kēia ke hoʻopili i ke ʻano o ka lapaʻau e ʻoi aku ka maikaʻi iā ʻoe, a pehea e holomua ai ka lymphoma me ka mālama ʻole ʻana. E kōkua iā ʻoe e hoʻolālā i mua, ʻike i ka mea e manaʻo ai a kōkua iā ʻoe e nīnau i kāu kauka i nā nīnau kūpono.
Hoʻohui hou ʻia nā lymphomas i loko o nā lymphoma palaualelo a i ʻole aggressive lymphomas.
ʻO Lymphoma ʻAʻole
ʻO nā lymphomas Indolent nā lymphoma e ulu lohi nei e "moe" pinepine a ulu ʻole. ʻO ia ke ʻano o lākou i loko o kou kino, ʻaʻole naʻe e hana ʻino. ʻAʻole pono ka nui o nā lymphoma molowa i kahi lapaʻau - ʻoiai inā e hiamoe ana lākou. ʻOiai ʻo kekahi pae kiʻekiʻe, ʻaʻole pono i nā lymphoma molowa e like me ka pae 3 a me ka pae 4 ke mālama ʻia, inā ʻaʻole ia e hōʻike i nā hōʻailona a ʻaʻole e ulu ikaika.
ʻAʻole hiki ke ho'ōla ʻia ka hapa nui o nā lymphoma palaualelo, no laila e loaʻa iā ʻoe ka lymphoma no ke koena o kou ola. Akā, hiki i nā poʻe he nui ke ola i ke ola maʻamau a me ke ola me kahi lymphoma palaka.
ʻAʻole paha ʻoe i ʻike ʻia nā hōʻailona ke loaʻa iā ʻoe kahi lymphoma palaualelo, a hiki ke noho pū me ia no nā makahiki he nui me ka pilikia ʻole. No kekahi poʻe, ʻaʻole hiki ke ʻike ʻia a hiki i kou hele ʻana i ke kauka a nānā ʻia no kahi mea ʻē aʻe.
Hoʻokahi o ʻelima mau kānaka me ka lymphoma palaualelo ʻaʻole pono e mālama i ko lākou lymphoma. Eia naʻe, hiki i nā lymphomas molowa ke "ala" a hoʻomaka e ulu. Inā loaʻa kēia, pono paha ʻoe e hoʻomaka i ka mālama ʻana. He mea nui e hōʻike i kāu kauka inā hoʻomaka ʻoe e loaʻa nā hōʻailona e like me nā puʻupuʻu hou a ulu paha (pehu lymph nodes) a i ʻole B-hōʻailona E like me:
- Hoʻohuʻu i ka hou o ka pō
- Ka hoʻoliʻiliʻi kaumaha ʻole
- Ka wela me ke anu a me ka haalulu.
I nā hihia koʻikoʻi, hiki i kahi lymphoma palaualelo ke "hoʻololi" i loko o kahi subtype koʻikoʻi o lymphoma. Inā loaʻa kēia, e hāʻawi ʻia iā ʻoe ka lāʻau like no ka lymphoma aggressive.
Aia ma lalo ka papa inoa o nā lymphoma maʻamau B-cell a me T-cell indolent lymphomas. Inā ʻike ʻoe i kāu subtype, a ua helu ʻia ma aneʻi, hiki iā ʻoe ke kaomi ma luna no ka ʻike hou aku.
ʻAi ʻole (ke ulu mālie) T-cell NHL
ʻO nā Lymphoma ʻinoʻino
ʻOi aku ka paʻakikī o ka mālama ʻana i nā lymphoma T-cell hōʻeuʻeu, a hiki ke kala ʻia ma hope o ka mālama ʻana. Eia naʻe, he mea maʻamau ka hoʻi hou ʻana o nā lymphomas T-cell a pono hou, a i ʻole ka mālama mau ʻana.
He mea nui e kamaʻilio me kāu kauka e pili ana i nā manaʻolana o kāu mālama ʻana, a pehea paha ʻoe e ola ai a i ʻole e kala ʻia.
Nā lāʻau lapaʻau no Lymphoma a me CLL
Ma muli o ka nui o nā ʻano like ʻole o ka lymphoma, nui nō hoʻi nā ʻano lapaʻau like ʻole. I ka hana ʻana i kāu hoʻolālā lapaʻau e noʻonoʻo kāu kauka i kēia mau mea āpau me:
- He aha ka subtype a me ka pae o ka lymphoma iā ʻoe.
- Loaʻa iā ʻoe nā hoʻololi genetic.
- ʻO kou mau makahiki, ke olakino holoʻokoʻa a me nā lāʻau lapaʻau ʻē aʻe āu e loaʻa ai no nā maʻi ʻē aʻe.
- Inā ua loaʻa iā ʻoe ka lāʻau lapaʻau no ka lymphoma i ka wā ma mua a inā pēlā, pehea ʻoe i pane ai i kēlā lapaʻau.
Nā nīnau no kāu kauka
Hiki ke paʻakikī ke loaʻa iā ʻoe ka lymphoma a i ʻole CLL. A inā ʻaʻole ʻoe i ʻike i ka mea āu i ʻike ʻole ai, pehea ʻoe e ʻike ai i nā nīnau e nīnau ai?
No ke kōkua ʻana iā ʻoe e hoʻomaka, ua hoʻokomo mākou i kekahi mau nīnau e hiki iā ʻoe ke paʻi a lawe i kāu hālāwai aʻe. E kaomi wale i ka loulou ma lalo nei e kiʻi i kā mākou mau nīnau e nīnau i kāu kauka.
Aia kekahi ʻano maʻi maʻi koko ʻē aʻe?
Loaʻa iā mākou nā ʻano ʻokoʻa koko keʻokeʻo e pāʻani ana i nā kuleana like ʻole i ka hakakā ʻana i nā maʻi a me nā maʻi. ʻO ka Lymphoma kahi maʻi maʻi o ke koko keʻokeʻo i kapa ʻia he lymphocytes. Akā, no ka loaʻa ʻana o nā ʻano ʻokoʻa o ke koko keʻokeʻo, aia nā ʻano maʻi maʻi koko ʻē aʻe, me ka leukemia a me ka myeloma.
Leukemia
Hoʻopilikia ka maʻi maʻi maʻi i nā ʻano like ʻole o ke koko keʻokeʻo. Hoʻoulu ʻia nā cell abnormal i ka iwi iwi a i ʻole ke kahe koko. Me ka ma'i ma'i leukemia, 'a'ole hana 'ia ke koko e like me ka mea e pono ai. He nui loa, he kakaikahi paha, a i ole ia na keena koko i hana ole e like me ka pono.
Hiki ke hoʻokaʻawale ʻia ka maʻi maʻi maʻi ma muli o ke ʻano o ke keʻokeʻo keʻokeʻo i hoʻopilikia ʻia, a i ʻole he myeloid cell a i ʻole lymphatic cell, a pehea ka holomua o ka maʻi. E ulu koke ana ka ma'i ma'i leukemia ma'i a pono e lapa'au koke 'ia, a'o ka ma'i ma'i ma'i ma'i ma'i e ulu ana no ka manawa lō'ihi, a 'a'ole pono e lapa'au.
No ka 'ike hou aku, e 'ike i ka Pūnaewele Pūnaewele Leukemia.
Myeloma
ʻO ka Myeloma kahi maʻi maʻi o kahi loea kūikawā, a ʻo ke ʻano oʻo loa o ka lymphocyte B-cell - i kapa ʻia he cell plasma. ʻO ia ka cell plasma e hana ana i nā antibodies (i kapa ʻia ʻo immunoglobulins). No ka loaʻa ʻana o kēia hana kūikawā, ʻokoʻa ka myeloma i nā lymphomas.
I ka myeloma, hoʻokahi wale nō ʻano o ka antibody i kapa ʻia he paraprotein. ʻAʻohe hana pono o kēia paraprotein, a ke hōʻiliʻili ka nui o nā cell plasma abnormal i loko o kou iwi iwi, paʻakikī paha kou kino e hakakā i ka maʻi.
No ka 'ike hou aku, e 'ike i ka Pūnaewele ʻo Myeloma Australia.
hōʻuluʻulu manaʻo
- ʻO Lymphoma kahi ʻano maʻi maʻi koko e pili ana i nā keʻokeʻo keʻokeʻo i kapa ʻia he lymphocytes.
- Noho nui nā Lymphocytes i loko o kā mākou ʻōnaehana lymphatic a kākoʻo i ko mākou ʻōnaehana pale ma ke kaua ʻana i nā maʻi a me nā maʻi.
- Hoʻomaka ʻo Lymphoma i ka wā e hoʻololi ai kā mākou DNA i ka ulu ʻole a me ka ulu ʻole o nā pūnaeho lymphoma maʻi kanesa.
- ʻO Hodgkin Lymphoma a me Non-Hodgkin Lymphoma nā ʻano nui o ka lymphoma, akā ua hoʻokaʻawale ʻia lākou he lymphomas B-cell a i ʻole T-cell lymphomas, a me nā lymphoma indolent a i ʻole aggressive.
- Nui nā ʻano lāʻau lapaʻau like ʻole a ʻo ka pahuhopu o ka mālama ʻana e hilinaʻi ʻia ma ke ʻano subtype o lymphoma i loaʻa iā ʻoe.
- Inā ʻaʻole ʻoe ʻike i ke ʻano subtype o kāu lymphoma, a i ʻole ke koʻikoʻi o kāu ʻano subtype, e nīnau i kāu kauka.
